Been on metformin for a month. Only first two days had a bad headache. When I started taking it I was 102kg heavy. Now I'm 94kg. But I mean when I was diagnosed with insulin resistance I quit alcohol, sugar and lactose. Insulin is synthesized in and secreted from the β-cells within the islets of Langerhans in the pancreas. The normal pancreas has about 1 million islets, which constitute about 2-3% of the gland’s mass. Besides lowering your glucose and insulin levels, metformin may provide other health benefits to women with PCOS. Metformin can enhance ovulation and regulate menstrual cycles. Insulin resistance occurs most often in people who have a family history of the disorder, overweight people and women who have polycystic ovary disease, a hormonal disorder characterized by insulin resistance and an over-production of male hormones called androgens. Metformin is used to treat people with type 2 diabetes. It is sometimes used in combination with insulin or other medications. Learn about side effects, interactions and indications. Metformin doesn't typically cause blood pressure to plummet and lead to hypoglycemia, but it canand that can cause headaches. GLP-1 is an incretin hormone secreted in the gut which stimulates the beta cell to secrete insulin in the presence of high blood sugars. Metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet) is a prescription drug used for treating type 2 diabetes in adults and children. Side effects, storage and dosing information, drug interactions, and pregnancy safety are provided. Medical uses. Metformin is primarily used for type 2 diabetes, but is also used in polycystic ovary syndrome. Outcomes appear to be improved even in those with some degree of kidney disease, heart failure, or liver problems. INTRODUCTION. In normal individuals, fasting plasma glucose levels range from about 60 to 100 mg/dL (3.3 to 5.6 mmol/L). In patients with diabetes mellitus, insulin deficiency or insulin resistance leads to a state of hyperglycemia. Metformin is a type of medication used to treat Type 2 Diabetes. Because there is a strong link between diabetes and PCOS, metformin is now commonly proscribed to treat PCOS.